C-terminal domain of transcription cofactor PC4 reveals dimeric ssDNA binding site.

C-terminal domain of transcription cofactor PC4 reveals dimeric ssDNA binding site.

Nature structural biology (1997-11-14)

J Brandsen, S Werten, P C van der Vliet, M Meisterernst, J Kroon, P Gros

摘要

The crystal structure of human replication and transcription cofactor PC4CTD reveals a dimer with two single-stranded (ss)DNA binding channels running in opposite directions to each other. This arrangement suggests a role in establishment or maintenance of melted DNA at promoters or origins of replication.