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Merck
  • Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120).

Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120).

Bioorganic & medicinal chemistry letters (2014-06-03)
Steven M Sparks, Grace Chen, Jon L Collins, Dana Danger, Steven T Dock, Channa Jayawickreme, Stephen Jenkinson, Christopher Laudeman, M Anthony Leesnitzer, Xi Liang, Patrick Maloney, David C McCoy, David Moncol, Vincent Rash, Thomas Rimele, Padmaja Vulimiri, James M Way, Sean Ross
PMID24881566
摘要

The exploration of a diarylsulfonamide series of free fatty acid receptor 4 (FFA4/GPR120) agonists is described. This work led to the identification of selective FFA4 agonist 8 (GSK137647A) and selective FFA4 antagonist 39. The in vitro profile of compounds 8 and 39 is presented herein.