跳轉至內容
Merck
  • Gene induction by Phenobarbital: an update on an old question that receives key novel answers.

Gene induction by Phenobarbital: an update on an old question that receives key novel answers.

Pharmacology & toxicology (2001-10-09)
L Corcos, D Lagadic-Gossmann
摘要

Phenobarbital has long been used as a sedative and antiepileptic drug. The drug is the representative of a myriad of lipophilic molecules able to evoke a pleiotropic response in the liver and also in prokaryotes and flies. A great deal of novel information has been obtained in recent years regarding the mechanism of cytochrome P450 (CYP) gene induction by phenobarbital. Most importantly, a nuclear orphan receptor, the constitutive androstane receptor has been identified as a primary determinant of the transcriptional activation of CYP genes in response to phenobarbital-like inducers in mammals. Another nuclear receptor, the pregnane X receptor can also mediate some of the phenobarbital response, but the functional overlap of the two inductive pathways is only partial. The response of mammalian CYP2B genes to phenobarbital was abolished in the liver of mice carrying a null allele of the constitutive androstane receptor gene, whereas that of CYP3A genes was lost in pregnane X receptor knock-out mice.

材料
產品編號
品牌
產品描述

Supelco
苯巴比妥标准液 溶液, 1 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
庫存單位
包裝尺寸
供貨能力
價格
數量
Sigma-Aldrich
苯巴比妥米那
庫存單位
包裝尺寸
供貨能力
價格
數量