- Rational engineering of Candida antarctica lipase B for selective monoacylation of diols.
Rational engineering of Candida antarctica lipase B for selective monoacylation of diols.
Chemical communications (Cambridge, England) (2012-09-05)
Anders Hamberg, Steffen Maurer, Karl Hult
PMID22945018
摘要
The enzyme Candida antarctica lipase B was subjected to site directed mutagenesis suggested by molecular modelling. The selectivity for the enzyme increased towards a range of diols over their corresponding monoesters as an effect of the mutations.