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  • Formation of N-nitrosodiphenylamine from 1,1-diphenylhydrazine by rat liver microsomal preparations.

Formation of N-nitrosodiphenylamine from 1,1-diphenylhydrazine by rat liver microsomal preparations.

Biochemical and biophysical research communications (1984-02-14)
K Tatsumi, S Kitamura, M Sumida
摘要

The present study provides the first evidence for in vitro metabolic conversion of a 1,1-disubstituted hydrazine to the corresponding nitrosamine. The study shows that superoxide radical which is generated by NADPH-cytochrome c reductase is involved in the oxidation of 1,1-diphenylhydrazine to N-nitrosodiphenylamine catalyzed by rat liver microsomes.

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N,N-二苯肼盐酸盐, 97%
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