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Merck
  • Anti-inflammatory effect of visnagin in lipopolysaccharide-stimulated BV-2 microglial cells.

Anti-inflammatory effect of visnagin in lipopolysaccharide-stimulated BV-2 microglial cells.

Archives of pharmacal research (2010-12-01)
Jin-Koo Lee, Jun-Sub Jung, Sang-Hee Park, Soo-Hyun Park, Yun-Beom Sim, Seon-Mi Kim, Tal-Soo Ha, Hong-Won Suh
摘要

Visnagin, which is found in Ammi visnaga, has biological activity as a vasodilator and reduces blood pressure by inhibiting calcium influx into the cell. The present study demonstrates the anti-inflammatory effect of visnagin on lipopolysaccharide (LPS)-stimulated BV-2 microglial cells. When cells were treated with visnagin prior to LPS stimulation, production of nitric oxide and expression of iNOS were attenuated in a dose-dependent manner. Visnagin also caused a significant decrease of mRNA expression and release of TNF-α, IL-1β and IFNγ. In addition, visnagin reduced LPS-induced IL-6 and MCP-1 mRNA level. We further found that visnagin dose-dependently inhibited LPS-induced AP-1 and NF-κB luciferase activities. Taken together, our results for the first time suggest that the anti-inflammatory effect of visnagin might result from the inhibition of transcription factors, such as AP-1 and NF-κB.

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凯林, for microscopy