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Merck
  • Redox cycling of adrenaline and adrenochrome catalysed by mitochondrial Complex I.

Redox cycling of adrenaline and adrenochrome catalysed by mitochondrial Complex I.

Archives of biochemistry and biophysics (2006-02-21)
Maria Luisa Genova, Nagwa M Abd-Elsalam, El Sayed M E Mahdy, Andrea Bernacchia, Marco Lucarini, Gian Franco Pedulli, Giorgio Lenaz
摘要

Complex I in bovine heart submitochondrial particles catalyses the NADH-supported generation of superoxide anion; adrenaline is oxidised by superoxide to adrenochrome that, on its hand, is reduced by Complex I, thus establishing a redox cycle that amplifies the superoxide production. The routes in Complex I for superoxide formation and for adrenochrome reduction appear to be different, since they have a different sensitivity to Complex I inhibitors. The results are discussed in terms of current assays for superoxide detection and of pathologies linked to catecholamine oxidation.

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肾上腺色素, ≥95% (HPLC)