- Synthesis of novel spiropyrrolizidines as potent antimicrobial agents for human and plant pathogens.
Synthesis of novel spiropyrrolizidines as potent antimicrobial agents for human and plant pathogens.
Bioorganic & medicinal chemistry letters (2008-03-18)
Govindasami Periyasami, Raghavachary Raghunathan, Gangadharan Surendiran, Narayanasamy Mathivanan
PMID18342506
摘要
A series of novel dispirooxindolopyrrolizidine derivatives have been synthesized through 1,3-dipolar cycloaddition reaction of azomethine ylide generated from proline and isatin with the dipolarophile (E)-2-arylidine-1-keto carbazoles. The synthesized cycloadducts were evaluated for antimicrobial activities. Compounds 7d and 7e showed relatively good antibacterial and antifungal activities.