IRAK-4 inhibitors. Part 1: a series of amides.

IRAK-4 inhibitors. Part 1: a series of amides.

Bioorganic & medicinal chemistry letters (2008-05-14)

George M Buckley, Lewis Gowers, Alicia Perez Higueruelo, Kerry Jenkins, Stephen R Mack, Trevor Morgan, David M Parry, William R Pitt, Oliver Rausch, Marianna D Richard, Verity Sabin, Joanne L Fraser

PMID18474425

摘要

The synthesis and profile of a series of amides are described. Some of these compounds were potent IRAK-4 inhibitors and two examples were evaluated in vivo.