跳轉至內容
Merck
  • Review of the in vivo functions of the p160 steroid receptor coactivator family.

Review of the in vivo functions of the p160 steroid receptor coactivator family.

Molecular endocrinology (Baltimore, Md.) (2003-06-14)
Jianming Xu, Qingtian Li
摘要

The p160 steroid receptor coactivator (SRC) gene family contains three homologous members, which serve as transcriptional coactivators for nuclear receptors and certain other transcription factors. These coactivators interact with ligand-bound nuclear receptors to recruit histone acetyltransferases and methyltransferases to specific enhancer/promotor regions, which facilitates chromatin remodeling, assembly of general transcription factors, and transcription of target genes. This minireview summarizes our current knowledge about the molecular structures, molecular mechanisms, temporal and spatial expression patterns, and biological functions of the SRC family. In particular, this article highlights the roles of SRC-1 (NCoA-1), SRC-2 (GRIP1, TIF2, or NCoA-2) and SRC-3 (p/CIP, RAC3, ACTR, AIB1, or TRAM-1) in development, organ function, endocrine regulation, and nuclear receptor function, which are defined by characterization of the genetically manipulated animal models. Furthermore, this article also reviews our current understanding of the role of SRC-3 in breast cancer and discusses possible mechanisms for functional specificity and redundancy among SRC family members.

材料
產品編號
品牌
產品描述

Sigma-Aldrich
SRC1 (627-786), biotin, untagged human, recombinant, expressed in E. coli, ≥80% (SDS-PAGE)