SRP8058

Tim-4 (human): FC (human)

recombinant, expressed in CHO cells, ≥98% (SDS-PAGE)

• 同義詞: PC cell-derived growth factor, TIM4, TIMD4
• 分類程式碼代碼: 12352200
• NACRES: NA.32

屬性

• 生物源: human
• 重組細胞: expressed in CHO cells
• 化驗: ≥98% (SDS-PAGE)
• 形狀: lyophilized
• 分子量: monomer 54 kDa by calculation
• 包裝: pkg of 100 μg
• 雜質: <0.06 EU/μg endotoxin, tested
• 顏色: white
• UniProt登錄號: Q96H15
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• 基因資訊: mouse ... Timd4(276891)

描述

一般說明

The TIM (T cell/transmembrane, immunoglobulin and mucin) family plays a critical role in regulating immune responses, including allergy, asthma, transplant tolerance, autoimmunity and the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. TIM-4 (T cell; immunoglobulin; Mucin-4), also known as SMUCKLER, is a 60 kDa member of the TIM family of immune regulating proteins. TIM-4 is exclusively expressed on antigen-presenting cells, where it mediates phagocytosis of apoptotic cells and plays an important role in maintaining tolerance. TIM-4 binds specifically to TIM-1 which is also the cellular receptor for the hepatitis A virus, and has been implicated in the development of asthma. Among hematopoietic cells, TIM-1 is expressed on activated B and T cells, preferentially in the Th2 subset of CD4+ T cells. The interaction of TIM-4 with TIM-1 induces costimulatory and hyperproliferative signals in T cells.

外觀

Lyophilized from 0.2 μm-filtered solution in PBS.

重構

Reconstitute at 100 μg/mL in sterile PBS.

其他說明

The extracellular domain of mouse Tim-4 (aa 22-279) is fused to the N-terminus of the Fc region of human IgG1.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable