SML1467

ASP7663

≥98% (HPLC)

• 同義詞: (2E)-2-[7-Fluoro-1,2-dihydro-1-(2-methylpropyl)-2-oxo-3H-indol-3-ylidene]acetic acid, (E)-[7-Fluoro-1-(2-methylpropyl)-2-oxo-1,2-dihydro-3H-indol-3-ylidene]acetic acid
• 經驗公式（希爾表示法）: C₁₄H₁₄FNO₃
• CAS號碼: 1190217-35-6
• 分子量：: 263.26
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329825901
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: light orange to dark orange
• 溶解度: DMSO: 25 mg/mL, clear
• 儲存溫度: 2-8°C
• SMILES 字串: CC(C)CN(C1=C(F)C=CC=C1/C2=C\C(O)=O)C2=O
• InChI: 1S/C14H14FNO3/c1-8(2)7-16-13-9(4-3-5-11(13)15)10(14(16)19)6-12(17)18/h3-6,8H,7H2,1-2H3,(H,17,18)/b10-6+
• InChI 密鑰: RCVZUIGCNAAMIC-UXBLZVDNSA-N

描述

生化／生理作用

ASP7663 is a selective activator of transient receptor potential ankyrin 1 (TRPA1), known to play a role for chemical sensing in the pain pathway. ASP7663 activated human, rat, and mouse TRPA1 receptors with EC₅₀ values of 510, 540, and 500 nM, respectively, and little or no affinity at more than 60 other related receptors, channels and enzymes. ASP7663 enhanced colonic motility and exerted analgesic effects against abdominal pain in mouse models.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable