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Key Documents

SAB4502117

Sigma-Aldrich

Anti-RXFP3 antibody produced in rabbit

affinity isolated antibody

同義詞:

G protein-coupled receptor SALPR, GPCR135, RLN3 receptor 1, Relaxin family peptide receptor 3, Somatostatin- and angiotensin-like peptide receptor

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

rabbit

品質等級

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

buffered aqueous solution

分子量

antigen 51 kDa

物種活性

rat, human, mouse

濃度

~1 mg/mL

技術

ELISA: 1:10000
western blot: 1:500-1:1000

NCBI登錄號

UniProt登錄號

運輸包裝

wet ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... RXFP3(51289)

相關類別

一般說明

Anti-RXFP3 Antibody detects endogenous levels of total RXFP3 protein.
RXFP3 (relaxin family peptide receptor 3) is also termed as GPCR 135/ SALPR (somatostatin- and angiotensin- like peptide receptor). It is distributed in the central nervous system (CNS), mainly in areas associated with memory, sensory and emotional processing. RXFP3 belongs to the insulin superfamily. This gene is mapped to human chromosome 5p13.

免疫原

The antiserum was produced against synthesized peptide derived from human RXFP3.

Immunogen Range: 161-210

生化/生理作用

RXFP3 (relaxin family peptide receptor 3) acts as the cognate receptor for relaxin-3. It controls feeding, motivated behaviors, stress and anxiety. RXFP3 system also modulates alcohol-seeking.

特點和優勢

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外觀

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

nwg

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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存取文件庫

Hydrocarbon stapled B chain analogues of relaxin-3 retain biological activity.
Jayakody T, et al.
Peptides, 84, 44-57 (2016)
Role of relaxin-3/RXFP3 system in stress-induced binge-like eating in female rats.
Calvez J, et al.
Neuropharmacology, 102, 207-215 (2016)
5p13. 3p13. 2 duplication associated with developmental delay, congenital malformations and chromosome instability manifested as low-level aneuploidy.
Iourov IY, et al.
SpringerPlus, 4(1), 616-616 (2015)
In vitro pharmacological characterization of RXFP3 allosterism: an example of probe dependency.
Alvarez-Jaimes L, et al.
PLoS ONE, 7(2), e30792-e30792 (2012)
Philip J Ryan et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(51), 20789-20794 (2013-12-04)
Relapse and hazardous drinking represent the most difficult clinical problems in treating patients with alcohol use disorders. Using a rat model of alcohol use and alcohol-seeking, we demonstrated that central administration of peptide antagonists for relaxin family peptide 3 receptor

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