F8257

氟桂嗪 二盐酸盐

≥98% (TLC)

• 同義詞: 1-[双(4-氟苯基)甲基]-4-(3-苯基-2-丙烯基)哌嗪 二盐酸盐
• 經驗公式（希爾表示法）: C₂₆H₂₆F₂N₂ · 2HCl
• CAS號碼: 30484-77-6
• 分子量：: 477.42
• Beilstein: 4284243
• EC號碼: 250-216-6
• MDL號碼: MFCD00058198
• 分類程式碼代碼: 12352200
• PubChem物質ID: 24277835
• NACRES: NA.77

屬性

• 化驗: ≥98% (TLC)
• 起源: Johnson & Johnson
• 儲存溫度: 2-8°C
• SMILES 字串: Cl[H].Cl[H].Fc1ccc(cc1)C(N2CCN(CC2)C\C=C\c3ccccc3)c4ccc(F)cc4
• InChI: 1S/C26H26F2N2.2ClH/c27-24-12-8-22(9-13-24)26(23-10-14-25(28)15-11-23)30-19-17-29(18-20-30)16-4-7-21-5-2-1-3-6-21;;/h1-15,26H,16-20H2;2*1H/b7-4+;;
• InChI 密鑰: RXKMOPXNWTYEHI-RDRKJGRWSA-N

描述

一般說明

Flunarizine has antihistamine, anticonvulsant and vestibular depressive properties. It protects endothelial cells from calcium overload-induced damage. Flunarizine is used to treat epilepsy, migraine prophylaxis, cerebral blood flow disturbances, peripheral vascular disease and vertigo.

應用

Flunarizine dihydrochloride has been used to study the effect of flunarizine on epileptiform activity. It is also used to study its effect on high-potassium induced increase of intracellular free calcium.

生化／生理作用

阻断 T 型 Ca²⁺/Na⁺ 通道；抑制嗜铬细胞中由 K⁺ 诱导的儿茶酚胺释放。

特點和優勢

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302
• 防範說明: P264 - P270 - P301 + P312 - P501
• 危險分類: Acute Tox. 4 Oral
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Gloves