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About This Item
經驗公式（希爾表示法）:
C11H9ClF3NO2
CAS號碼:
分子量：:
279.64
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
推薦產品
品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
white to off-white
溶解度
DMSO: >10 mg/mL
儲存溫度
room temp
SMILES 字串
CC(=O)CC(=O)Nc1ccc(Cl)c(c1)C(F)(F)F
InChI
1S/C11H9ClF3NO2/c1-6(17)4-10(18)16-7-2-3-9(12)8(5-7)11(13,14)15/h2-3,5H,4H2,1H3,(H,16,18)
InChI 密鑰
GNYIJZMBLZXJEJ-UHFFFAOYSA-N
應用
Fasentin已被用作葡萄糖转运蛋白（GLUT1）抑制剂，用于评估其对各种三阴性乳腺癌 (TNBC) 细胞系脆弱性的影响，并研究其对氢化可的松（HC）诱发的细胞毒性药物的作用。
生化／生理作用
Fastentin是一种葡萄糖摄入的全新抑制剂，GluT1抑制剂。Fastentin是一种全新的葡萄糖摄入抑制剂，可敏化细胞对FAS诱导的细胞死亡。Fastentin会选择性敏化死亡配体，但不会降低FLIP的表达。它会改变与营养和葡萄糖剥夺相关的基因表达。Fastentin可与葡萄糖转运蛋白GLUT1细胞间通道中一个独特的位点发生互作。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
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文章
We presents an article about the Warburg effect, and how it is the enhanced conversion of glucose to lactate observed in tumor cells, even in the presence of normal levels of oxygen. Otto Heinrich Warburg demonstrated in 1924 that cancer cells show an increased dependence on glycolysis to meet their energy needs, regardless of whether they were well-oxygenated or not.
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