推薦產品
生物源
Porcine pancreas
品質等級
化驗
≥95% (Lowry)
形狀
essentially salt-free, lyophilized powder
濃度
≥500 μ protein/vial
顏色
white to faint yellow
溶解度
H2O: soluble 1.9-2.1 mg/mL, clear, colorless to faintly yellow
適合性
suitable for molecular biology
UniProt登錄號
應用
food and beverages
儲存溫度
−20°C
基因資訊
pig ... CLPS(397407)
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一般說明
基因脂肪酶（CLPS）编码一种主要在外分泌胰腺中表达的脂肪酶。这种蛋白质也存在于胃肠道中。它的结构包括17个氨基酸信号肽和一个位于N端的5氨基酸前体片段。
Research Area: Cell Signaling
Colipase is a member of a group of small cysteine-rich proteins characterized by a limited secondary structure. Its structure is relatively flat, measuring 25×30×35 Å, resembling an arrangement of protruding fingers interconnected at one end by a complex network of five disulfide bridges. The colipase structure comprises two small domains with closely related topology.
Colipase is a member of a group of small cysteine-rich proteins characterized by a limited secondary structure. Its structure is relatively flat, measuring 25×30×35 Å, resembling an arrangement of protruding fingers interconnected at one end by a complex network of five disulfide bridges. The colipase structure comprises two small domains with closely related topology.
應用
来自猪胰腺的大肠酶已用于：
- 脂肪酶测定的酶液
- 在酶混合物中模拟肠胃消化
- 作为明显关键因素之一，研究对番茄红素体外可及性的影响
生化／生理作用
脂质酶参与脂质代谢和凋亡信号通路。它对脂肪消化至关重要。作为一种胰腺蛋白，它可以防止脂肪酶变性，并能够附着在液滴的脂-水间相。脂质酶使脂肪酶可接近三酰甘油的内芯。外分泌胰腺功能不足引起的脂质酶分泌缺陷使膳食脂肪的腔内水解降至最低水平。缺乏先天性脂肪酶或脂质酶导致胰腺脂肪吸收不良。
Colipase, a small protein cofactor, is essential for efficient dietary lipid hydrolysis by pancreatic lipase. It attaches to the non-catalytic C-terminal domain of the lipase, stabilizing an active conformation and significantly enhancing the overall hydrophobic binding site. This pancreatic exocrine protein aids in the adsorption of pancreatic triglyceride lipase (PTL) to the substrate lipid-water interface.
特點和優勢
- 克服胆汁盐对脂肪酶的抑制作用。
- 可以在三油精、脱氧胆酸钠、以及猪胰脂肪酶的乳浊液中通过比浊法对活性进行确定。
準備報告
以1.9-2.1 mg/mL浓度溶于水，形成透明、无色至淡黄色溶液。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
客戶也查看了
W Junge et al.
Clinica chimica acta; international journal of clinical chemistry, 123(3), 293-302 (1982-08-18)
Colipase, like other pancreatic proteins, is liberated into the circulation in acute pancreatitis. Its concentration was measured in serum by a turbidimetric and in urine by a titrimetric method. The principle of both assays is based on the reactivation of
Pancreatic colipase: chemistry and physiology.
B Borgström et al.
Journal of lipid research, 20(7), 805-816 (1979-09-01)
H van Tilbeurgh et al.
Biochimica et biophysica acta, 1441(2-3), 173-184 (1999-11-26)
Colipase is a small protein cofactor needed by pancreatic lipase for the efficient dietary lipid hydrolysis. It binds to the C-terminal, non-catalytic domain of lipase, thereby stabilising an active conformation and considerably increasing the overall hydrophobic binding site. Structural studies
Marcella Denaro et al.
Antioxidants (Basel, Switzerland), 10(2) (2021-01-28)
Recently, several studies have highlighted the role of Citrus flavanones in counteracting oxidative stress and inflammatory response in bowel diseases. The aim of study was to identify the most promising Citrus flavanones by a preliminary antioxidant and anti-inflammatory screening by
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