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Key Documents

571261

Sigma-Aldrich

哌啶

biotech. grade, ≥99.5%

同義詞:

六氢吡啶

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About This Item

經驗公式(希爾表示法):
C5H11N
CAS號碼:
分子量::
85.15
Beilstein:
102438
EC號碼:
MDL號碼:
分類程式碼代碼:
12352005
PubChem物質ID:
NACRES:
NA.21

等級

biotech. grade

品質等級

蒸汽密度

3 (vs air)

蒸汽壓力

23 mmHg ( 20 °C)

化驗

≥99.5%

形狀

liquid

技術

DNA sequencing: suitable

雜質

<0.3% water

折射率

n20/D 1.452 (lit.)

bp

106 °C (lit.)
106 °C

mp

−13 °C (lit.)

溶解度

organic solvents: soluble(lit.)
water: miscible(lit.)

密度

0.862 g/mL at 20 °C (lit.)

&lambda ;

1 cm path, H2O reference

紫外吸收

λ: 290 Amax: <1.000
λ: 370 Amax: <0.050

SMILES 字串

C1CCNCC1

InChI

1S/C5H11N/c1-2-4-6-5-3-1/h6H,1-5H2

InChI 密鑰

NQRYJNQNLNOLGT-UHFFFAOYSA-N

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一般說明

Piperidine, a heterocyclic cyclohexane is a volatile secondary amine. Maxam-Gilbert chemical method, a DNA sequencing technology employs piperidine to rupture DNA strands at damaged base site. Its crystal structure analyzed at 150K shows hydrogen bonding between NH groups. Piperidine ring forms a part of many naturally occuring alkaloids. It is prepared on an industrial scale by the hydrogenation of pyridine in the presence of nickel catalyst. The 1H NMR spectrum of piperidine has been recorded.

應用

适用于 Applied Biosystems 431 和 433A 多肽合成仪。
Piperidine has been used in combination with DMF (dimethylformamide) for the removal of Fmoc (fluorenylmethyloxycarbonyl) group from the N-terminal amino group during peptide synthesis.

訊號詞

Danger

危險分類

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B

儲存類別代碼

3 - Flammable liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

60.8 °F - closed cup

閃點(°C)

16 °C - closed cup


分析證明 (COA)

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W B Mattes et al.
Biochimica et biophysica acta, 868(1), 71-76 (1986-10-16)
The volatile, secondary amine piperidine is used in the Maxam-Gilbert chemical method of DNA sequencing to create strand breaks in DNA at sites of damaged bases. As such it is often used in generalized studies of DNA damage to identify
Peptide Synthesis.
Miao Z and Cheng Z
Bio-protocol, 2(14) (2012)
Andrew Parkin et al.
Acta crystallographica. Section B, Structural science, 60(Pt 2), 219-227 (2004-03-16)
The crystal structures of piperazine, piperidine and morpholine have been determined at 150 K. All three structures are characterized by the formation of NH...N hydrogen-bonded chains. In piperazine these are linked to form sheets, but the chains are shifted so
Xuwang Chen et al.
Bioorganic & medicinal chemistry, 20(12), 3856-3864 (2012-05-18)
A novel series of piperidine-linked amino-triazine derivatives were designed, synthesized and evaluated for in vitro anti-HIV activity as non-nucleoside reverse transcriptase inhibitors on the basis of our previous work. Screening results indicated that most compounds showed excellent activity against wild-type
Marek Łuczkowski et al.
Inorganic chemistry, 47(23), 10875-10888 (2008-10-31)
A de novo protein design strategy provides a powerful tool to elucidate how heavy metals interact with proteins.Cysteine derivatives of the TRI peptide family (Ac-G(LKALEEK)4G-NH2) have been shown to bind heavy metals in an unusual trigonal geometry. Our present objective

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