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Merck
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文件

60063

Sigma-Aldrich

酒石酸氧锑钾 三水合物

purum p.a., 99.0-103% (RT)

同義詞:

吐酒石, 酒石酸钾锑 三水合物

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About This Item

經驗公式（希爾表示法）:
C8H4K2O12Sb2 · 3H2O
CAS號碼:
28300-74-5
分子量：:
667.87
EC號碼:
234-293-3
MDL號碼:
MFCD00167056
分類程式碼代碼:
12352100
PubChem物質ID:
57651716
NACRES:
NA.21

等級

purum p.a.

品質等級

200

化驗

99.0-103% (RT)

損耗

≤2.7% loss on drying

mp

≥300 °C (lit.)

負離子痕跡

chloride (Cl-): ≤100 mg/kg
sulfate (SO42-): ≤500 mg/kg

正離子痕跡

Ca: ≤50 mg/kg
Cd: ≤50 mg/kg
Co: ≤50 mg/kg
Cu: ≤50 mg/kg
Fe: ≤50 mg/kg
Na: ≤500 mg/kg
Ni: ≤50 mg/kg
Pb: ≤50 mg/kg
Zn: ≤50 mg/kg

SMILES 字串

O.O.O.[K+].[K+].O=C1O[Sb-]23OC1C4O[Sb-]5(OC(C(O2)C(=O)O3)C(=O)O5)OC4=O

InChI

1S/2C4H4O6.2K.3H2O.2Sb/c2*5-1(3(7)8)2(6)4(9)10;;;;;;;/h2*1-2H,(H,7,8)(H,9,10);;;3*1H2;;/q2*-2;2*+1;;;;2*+3/p-4

InChI 密鑰

WBTCZEPSIIFINA-UHFFFAOYSA-J

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相關類別

一般說明

酒石酸锑钾三水合物是一种三价锑化合物。有报告称它是一种利什曼原虫化合物，并且与五价锑 (葡萄糖酸锑钠) 相比，对利什曼原虫显示出更大的毒性作用。 有报告称三维 X 线和白色辐射中子衍射方法曾用于研究其旋光体的晶体结构（二钾二-μ-d-酒石酸 (4)-双（锑酸盐 (III) 三水合物）。报告的晶胞尺寸为：a = 11.192 (2)、b = 11.696 (3) 和 c = 25.932(5)Å。

應用

酒石酸锑钾三水合物可用作含 Sb (III) 的药物，以研究其诱导与婴儿利什曼原虫 的无菌无鞭毛体 DNA 断裂相关的细胞死亡的能力。

象形圖

Skull and crossbonesEnvironment
GHS06,GHS09

訊號詞

Danger

危險分類

Acute Tox. 3 Oral - Acute Tox. 4 Inhalation - Aquatic Chronic 2 - Skin Irrit. 2 - Skin Sens. 1

儲存類別代碼

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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分析證明 (COA)

Lot/Batch Number
BCCF4925
BCCF2004
BCBZ4291
BCBZ3132
BCBT4747

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X-ray and white radiation neutron diffraction studies of optically active potassium antimony tartrate, K2Sb2(dC4H2O6)2? 3H2O (tarter emetic).
Gress ME and Jacobson RA.
Inorgorganica Chimica Acta, 8, 209-217 (1974)
D Sereno et al.
Antimicrobial agents and chemotherapy, 42(12), 3097-3102 (1998-12-03)
The mechanism(s) of activity of pentavalent antimony [Sb(V)] is poorly understood. In a recent study, we have shown that potassium antimonyl tartrate, a trivalent antimonial [Sb(III)], was substantially more potent than Sb(V) against both promastigotes and axenically grown amastigotes of
Susan Wyllie et al.
Biochemical pharmacology, 71(3), 257-267 (2005-12-02)
Trivalent antimonial compounds (Sb(III)), originally used in the treatment of leishmaniasis, are now being proposed as a novel therapy for acute promyelocytic leukaemia (APL). Here, we examine the effects of Sb(III) and pentavalent antimonial drugs (Sb(V)) on glutathione homeostasis, oxidative
Avijit Sarkar et al.
Cytometry. Part A : the journal of the International Society for Analytical Cytology, 79(1), 35-45 (2010-12-25)
Nitric oxide (NO) has been demonstrated to be a principal effector molecule responsible for mediating intracellular killing of Leishmania parasites, the causative organism of leishmaniasis. As measurement of intracellular NO remains a challenge to biologists, we have developed a flow
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