推薦產品
一般說明
抗CDH1（Ab-2），小鼠单克隆，克隆DH01，可识别大鼠1细胞中约55 kDa Cdh-1蛋白。它已被验证可用于蛋白质印迹和免疫沉淀。
用指定的免疫原免疫BALB/c小鼠，并将脾细胞与Sp2/0小鼠骨髓瘤融合而产生的纯化的小鼠单克隆抗体。识别约为55 kDa的ID1蛋白。
识别大鼠1细胞中~55 kDa Cdh-1蛋白。
免疫原
人
重组人Cdh1蛋白
應用
免疫印迹（1 g/mL）
免疫沉淀（2 g/mg蛋白裂解物）
包裝
请参考特定浓度批号的标签。
警告
毒性：标准处理（A）
外觀
在10 mM PBS，0.2%BSA，pH值7.4中。
分析報告
阳性对照
：KAT或LS174T细胞
：KAT或LS174T细胞
阴性对照
正常小鼠血清
正常小鼠血清
其他說明
Kramer, E.R., et al. 2000 Mol.Biol. Cell11, 1555.
Petersen, B.O., et al. 2000 Genes Dev.14, 2330.
Pfleger, C.M., et al. 2001 Genes Dev.15, 1759.
Sorensen, C.S., et al. 2001 Mol.Cell Biol.21, 3692.
Gieffers, C., et al. 1999 Proc.Natl.Acad.Sci. USA96, 11317.
Visintin, R., et al. 1997 Science278, 460.
Petersen, B.O., et al. 2000 Genes Dev.14, 2330.
Pfleger, C.M., et al. 2001 Genes Dev.15, 1759.
Sorensen, C.S., et al. 2001 Mol.Cell Biol.21, 3692.
Gieffers, C., et al. 1999 Proc.Natl.Acad.Sci. USA96, 11317.
Visintin, R., et al. 1997 Science278, 460.
不与其他含有WD重复序列的蛋白质（包括Cdc20）发生交叉反应。在单个系统中，应对抗体进行滴定以获得最佳结果。
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
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儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Hidefumi Fukushima et al.
Cell reports, 1(5), 434-443 (2012-06-19)
The NFkB/Rel family of proteins play critical roles in a variety of cellular processes. Thus, their physiological activation is tightly controlled. Recently, the NFkB2/p100 precursor has been characterized as the fourth IkB type of suppressor for NFkB. However, the molecular
Dipankar Ray et al.
Molecular and cellular biology, 25(8), 3338-3347 (2005-03-31)
Ubiquitin-dependent degradation of Cdc25A is a major mechanism for damage-induced S-phase checkpoint. Two ubiquitin ligases, the Skp1-cullin-beta-TrCP (SCFbeta-TrCP) complex and the anaphase-promoting complex (APCCdh1), are involved in Cdc25A degradation. Here we demonstrate that the transforming growth factor beta (TGF-beta)-Smad3 pathway
Jia Liu et al.
Cell discovery, 2, 15044-15044 (2016-07-28)
Anaphase-promoting complex/cyclosome/Cdh1 is a multi-subunit ubiquitin E3 ligase that drives M to G1 cell cycle progression through primarily earmarking various substrates for ubiquitination and subsequent degradation by the 26S proteasome. Notably, emerging evidence suggested that Cdh1 could also function in
Kyung Uk Hong et al.
The Journal of biological chemistry, 284(24), 16501-16512 (2009-04-17)
During mitosis, establishment of structurally and functionally sound bipolar spindles is necessary for maintaining the fidelity of chromosome segregation. Tumor-associated microtubule-associated protein (TMAP), also known as cytoskeleton-associated protein 2 (CKAP2), is a mitotic spindle-associated protein whose level is frequently up-regulated
Savvas C Pavlides et al.
Cell cycle (Georgetown, Tex.), 15(7), 931-947 (2016-03-11)
We previously reported that aberrant TGF-β/Smad2/3 signaling in endometrial cancer (ECA) leads to continuous ubiquitylation of p27(kip1)(p27) by the E3 ligase SCF-Skp2/Cks1 causing its degradation, as a putative mechanism involved in the pathogenesis of this cancer. In contrast, normal intact
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