513033

PD 168393

A potent, cell-permeable, irreversible, ATP-competitive and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC₅₀ = 700 pM).

• 同義詞: PD 168393, 4-[(3-Bromophenyl)amino]-6-acrylamidoquinazoline
• 經驗公式（希爾表示法）: C₁₇H₁₃BrN₄O
• CAS號碼: 194423-15-9
• 分子量：: 369.22
• MDL號碼: MFCD02179207
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: yellow
• 溶解度: DMSO: 200 mg/mL
• 運輸包裝: ambient
• 儲存溫度: −20°C
• InChI: 1S/C17H13BrN4O/c1-2-16(23)21-13-6-7-15-14(9-13)17(20-10-19-15)22-12-5-3-4-11(18)8-12/h2-10H,1H2,(H,21,23)(H,19,20,22)
• InChI 密鑰: HTUBKQUPEREOGA-UHFFFAOYSA-N

描述

一般說明

A potent, cell-permeable, irreversible, ATP-competitive and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC₅₀ = 0.70 nM). Does not inhibit other protein kinases. Acts by binding to the catalytic domain of the EGFR with a 1:1 stoichiometry and alkylating Cys⁷⁷³. Excellent antitumor agent in vivo.

A potent, cell-permeable, irreversible, ATP-competitive and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC₅₀ = 700 pM). Does not inhibit other protein kinases. Acts by binding to the catalytic domain of the EGFR with a 1:1 stoichiometry and alkylating Cys⁷⁷³. Excellent antitumor agent in vivo.

生化／生理作用

Cell permeable: yes

Primary Target
EGFR

Product competes with ATP.

Reversible: no

Target IC₅₀: 700 pM against EGFR

包裝

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid freeze/thaw cycles of solutions.

其他說明

Fry, D.W., et al. 1998. Proc. Natl. Acad. Sci USA 95, 12022.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable