14-934-M

GCN2, active

• 分類程式碼代碼: 12352200
• eCl@ss: 32160405
• NACRES: NA.32

屬性

• 生物源: human
• 品質等級: 100
• 分子量: M_w 215 kDa
• 製造商／商標名: Upstate^®
• 技術: activity assay: suitable (kinase)
• NCBI登錄號: NP_001013725
• UniProt登錄號: Q9P2K8
• 基因資訊: human ... EIF2AK4(440275)

描述

一般說明

GCN2 (EIF2AK4) belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2S1) to downregulate protein synthesis in response to varied cellular stresses.

Product Source: N-terminal GST-tagged, recombinant, human GCN2 full length, expressed by baculovirus in Sf21 insect cells. The recombinant protein contains the amino acid substitution E556G with reference to GenPept NP_001013725. E556G is reported in GenPept CAH10626.

生化／生理作用

Target Sub-Family: STE

包裝

Also available in 250μg size as catalog # 14-934M and in bulk as catalog # 14-934-K.

品質

Routinely evaluated by phosphorylation of peptide RSRSRSRSRSRSRSR

外觀

Purified using glutathione sepharose.

Protein in 50mM Tris/HCl pH7.5, 300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution.

儲存和穩定性

6 months at -70°C

其他說明

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

法律資訊

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H317
• 防範說明: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• 危險分類: Skin Sens. 1
• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable