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Key Documents

857230P

Avanti

C18:1 LPA

1-(9Z-octadecenyl)-2-hydroxy-sn-glycero-3-phosphate (ammonium salt), powder

同義詞:

1-O-9-(Z)-十八烯基-sn-甘油-3-磷酸酯(铵盐); PA(18:1(9Z)e/0:0)

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About This Item

經驗公式(希爾表示法):
C21H46NO6P
CAS號碼:
分子量::
439.57
分類程式碼代碼:
51191904
NACRES:
NA.25

化驗

>99% (LPA; may contain up to 10% of the 2-LPA isomer, TLC)

形狀

powder

包裝

pkg of 1 × 1 mg (857230P-1mg)

製造商/商標名

Avanti Research - A Croda Brand 857230P

脂質類型

cardiolipins
phospholipids

運輸包裝

dry ice

儲存溫度

−20°C

SMILES 字串

O[C@](COP([O-])(O)=O)([H])COCCCCCCCC/C=C\CCCCCCCC.[NH4+]

一般說明

C18:1 LPA是一种生物活性脂质。该溶血磷脂酸(LPA)是从膜磷脂中获得的可溶性脂质。它存在于血浆中。

應用

C18:1 LPA适合在萤光素酶测定中刺激人胚胎肾293(HEK 293)细胞。它还适合作为达尔伯克氏改良伊格尔培养基(DMEM)的添加剂,用于跨孔迁移试验、伤口愈合试验和细胞增殖试验。′

生化/生理作用

溶血磷脂酸(LPA)信号转导参与多种细胞过程。它还与神经系统疾病、炎症和癌症有关。

包裝

5 mL透明玻璃密封安瓿(857230P-1mg)

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

No data available

閃點(°C)

No data available


分析證明 (COA)

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R D Moreno-Fernández et al.
Neuropharmacology, 164, 107896-107896 (2019-12-08)
The LPA1 receptor, one of the six characterized G protein-coupled receptors (LPA1-6) through which lysophosphatidic acid acts, is likely involved in promoting normal emotional behaviours. Current data suggest that the LPA-LPA1-receptor pathway may be involved in mediating the negative consequences
Lysophosphatidic acid and its receptor LPA1 mediate carrageenan induced inflammatory pain in mice
Srikanth M, et al.
European Journal of Pharmacology, 841, 49- 56 (2018)
Autotaxin is a novel target of micro RNA-101-3p
Wang Y, et al.
FEBS Open Bio, 9(4), 707-716 (2019)
Jesica R Williams et al.
The Journal of biological chemistry, 284(25), 17304-17319 (2009-04-16)
Lysophosphatidic acid (LPA) is a ligand for LPA(1-3) of the endothelial differentiation gene family G-protein-coupled receptors, and LPA(4-8) is related to the purinergic family G-protein-coupled receptor. Because the structure-activity relationship (SAR) of GPR92/LPA(5) is limited and whether LPA is its

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