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Key Documents

C75004

Sigma-Aldrich

5-胆甾烯-3-酮

同義詞:

胆甾-5-烯-3-酮

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About This Item

經驗公式(希爾表示法):
C27H44O
CAS號碼:
分子量::
384.64
EC號碼:
MDL號碼:
分類程式碼代碼:
12352115
PubChem物質ID:
NACRES:
NA.22

形狀

powder

品質等級

mp

125-127 °C (lit.)

SMILES 字串

CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C

InChI

1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,22-25H,6-8,10-17H2,1-5H3/t19-,22+,23-,24+,25+,26+,27-/m1/s1

InChI 密鑰

GGCLNOIGPMGLDB-GYKMGIIDSA-N

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


分析證明 (COA)

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J P Slotte et al.
Biochimica et biophysica acta, 1145(2), 243-249 (1993-02-09)
In this study we have examined the cholesterol oxidase (Streptomyces cinnamomeus) catalyzed conversion of either 5-cholesten-3 beta-ol or 5-cholesten-3-one into 4-cholesten-3-one in pure sterol or mixed phospholipid-containing monolayers at the air/buffer interface. The mean molecular area requirement of 5-cholesten-3-one in
I J Kass et al.
Biochemistry, 37(51), 17990-18000 (1999-01-28)
Cholesterol oxidase catalyzes the oxidation and isomerization of cholesterol to cholest-4-en-3-one via cholest-5-en-3-one. It has been proposed that His447 acts as the general base catalyst for oxidation, and that the resulting imidazolium ion formed acts as an electrophile for isomerization.
Hui-Min Qin et al.
Protein expression and purification, 139, 1-7 (2017-07-18)
Cholesterol oxidases, which catalyze the degradation of cholesterol to cholest-4-en-3-one, are widely used in the pharmaceutical and food processing industries. The cholesterol oxidase from Pimelobacter simplex (PsChO3) was transformed into E. coli BL21(DE3), but it was expressed mainly as inclusion bodies
I J Kass et al.
Bioorganic & medicinal chemistry letters, 8(19), 2663-2668 (1999-01-05)
Cholesterol oxidase stereospecifically isomerizes cholest-5-en-3-one to cholest-4-en-3-one. When the base catalyst for isomerization, Glu361, is mutated to Asp, the rate of deprotonation of cholest-5-en-3-one is not affected, but protonation of the dienolic intermediate becomes rate-limiting. This may be a consequence
Khondker Rufaka Hossain et al.
Biochimica et biophysica acta. General subjects, 1863(8), 1243-1253 (2019-05-11)
Sterols have been reported to modulate conformation and hence the function of several membrane proteins. One such group is the Chloride Intracellular Ion Channel (CLIC) family of proteins. The CLIC protein family consists of six evolutionarily conserved protein members in

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