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Merck

SLC12A3

solute carrier family 12 (sodium/chloride transporter), member 3

同義詞:
NCC, NCCT, TSC
物種:
UniProtKB ID:
基因 ID:
  • Human(6559) Summary: This gene encodes a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis. This cotransporter mediates sodium and chloride reabsorption in the distal convoluted tubule. Mutations in this gene cause Gitelman syndrome, a disease similar to Bartter's syndrome, that is characterized by hypokalemic alkalosis combined with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. This cotransporter is the target for thiazide diuretics that are used for treating high blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(20497) solute carrier family 12, member 3
  • Rat(54300) solute carrier family 12 (sodium/chloride transporter), member 3
  • domestic guinea pig(100726300) solute carrier family 12 (sodium/chloride transporters), member 3
  • naked mole-rat(101704301) solute carrier family 12 (sodium/chloride transporters), member 3
  • cow(404171) solute carrier family 12 (sodium/chloride transporters), member 3
  • sheep(101120940) solute carrier family 12 (sodium/chloride transporters), member 3
  • Zebrafish(565439) solute carrier family 12 (sodium/chloride transporters), member 3
  • Horse(100051953) solute carrier family 12 (sodium/chloride transporters), member 3
  • domestic cat(101082284) solute carrier family 12 (sodium/chloride transporters), member 3
  • dog(478118) solute carrier family 12 (sodium/chloride transporters), member 3
  • chicken(415692) solute carrier family 12 (sodium/chloride transporters), member 3

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Antibodies

產品編號
描述
物種活性
應用
抗噻嗪敏感性NaCl协同转运蛋白抗体, Chemicon®, from rabbit,
物種活性
human, mouse, rabbit, rat
應用
immunohistochemistry
western blot
Anti-SLC12A3 antibody produced in rabbit, affinity isolated antibody,
物種活性
bovine, dog, guinea pig, horse, human, rabbit, rat
應用
western blot
Anti-SLC12A3 antibody produced in rabbit, 1 mg/mL, affinity isolated antibody,
物種活性
human, mouse, rat
應用
western blot

Small Molecule - Inhibitor

產品編號
描述
物種
氢氯噻嗪, United States Pharmacopeia (USP) Reference Standard,
物種
human
氢氯噻嗪, Pharmaceutical Secondary Standard; Certified Reference Material,
物種
human
Trichlormethiazide, United States Pharmacopeia (USP) Reference Standard,
物種
human
氯噻酮, United States Pharmacopeia (USP) Reference Standard,
物種
human
氯噻嗪, United States Pharmacopeia (USP) Reference Standard,
物種
human