PTEN
phosphatase and tensin homolog
同義詞:
10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1
物種:
Human PTEN (5728), Mouse Pten (19211), Rat Pten (50557), fruit fly Pten (43991), domestic cat PTEN (101091813), dog PTEN (403832), chicken PTEN (423675), cow PTEN (540786), sheep PTEN (101119351), domestic guinea pig Pten (100723659)
UniProtKB ID:
基因 ID:
- Human(5728) Summary: This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq, Jul 2008]
- Mouse(19211) phosphatase and tensin homolog
- Rat(50557) phosphatase and tensin homolog
- fruit fly(43991) CG5671 gene product from transcript CG5671-RB
- domestic cat(101091813) phosphatase and tensin homolog
- dog(403832) phosphatase and tensin homolog
- chicken(423675) phosphatase and tensin homolog
- cow(540786) phosphatase and tensin homolog
- sheep(101119351) phosphatase and tensin homolog
- domestic guinea pig(100723659) phosphatase and tensin homolog
- naked mole-rat(101714930) phosphatase and tensin homolog
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Antibodies
產品編號
描述
物種活性
應用
Anti-PTEN antibody, Rabbit monoclonal, clone SP218, recombinant, expressed in proprietary host, affinity isolated antibody,
物種活性
dog, frog, human, mouse
應用
flow cytometry
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-PTEN (Ab-370) antibody produced in rabbit, affinity isolated antibody,
物種活性
human, mouse, rat
應用
immunohistochemistry
western blot
western blot
Anti-PTEN antibody, Rabbit monoclonal, clone SP170, recombinant, expressed in proprietary host, affinity isolated antibody,
物種活性
dog, human, mouse
應用
flow cytometry
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-phospho-PTEN (pSer380/pThr382/pThr383) antibody produced in rabbit, affinity isolated antibody,
物種活性
human, mouse, rat
應用
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Monoclonal Anti-PTEN antibody produced in mouse, clone 3E7, purified immunoglobulin, buffered aqueous solution,
物種活性
human
應用
ELISA
immunofluorescence
immunoprecipitation (IP)
western blot
immunofluorescence
immunoprecipitation (IP)
western blot
esiRNA
產品編號
描述
物種