PSEN1
presenilin 1
同義詞:
AD3, FAD, PS-1, PS1, S182
物種:
Human PSEN1 (5663), Mouse Psen1 (19164), Rat Psen1 (29192), cow PSEN1 (282705), sheep PSEN1 (101102488), naked mole-rat Psen1 (101716186), Domestic Rabbit PSEN1 (100008886), domestic guinea pig Psen1 (100728153), Zebrafish psen1 (30221), domestic cat PSEN1 (101087239) ...更多
UniProtKB ID:
基因 ID:
- Human(5663) Summary: Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008]
- Mouse(19164) presenilin 1
- Rat(29192) presenilin 1
- cow(282705) presenilin 1
- sheep(101102488) presenilin 1
- naked mole-rat(101716186) presenilin 1
- Domestic Rabbit(100008886) presenilin 1
- domestic guinea pig(100728153) presenilin 1
- Zebrafish(30221) presenilin 1
- domestic cat(101087239) presenilin 1
- dog(403408) presenilin 1
- chicken(373977) presenilin 1
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Antibodies
Product Number
描述
物種活性
應用
Anti-Presenilin-1 Antibody, loop, a.a. 275-367, CT, serum, Chemicon®,
物種活性
hamster, human, monkey, mouse
應用
immunocytochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
抗早老素1抗体（NT，克隆hPS1-NT）, culture supernatant, clone hPS1-NT, Chemicon®,
物種活性
human
應用
ELISA
immunohistochemistry
immunoprecipitation (IP)
western blot
immunohistochemistry
immunoprecipitation (IP)
western blot
Anti-Presenilin1 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
物種活性
human, mouse, rat
應用
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Anti-Presenilin 1 antibody produced in rabbit, affinity isolated antibody,
物種活性
human
應用
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-PSEN1 antibody produced in rabbit, affinity isolated antibody,
物種活性
human, mouse, rat
應用
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot