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Merck

PRKG1

protein kinase, cGMP-dependent, type I

同義詞:
1, PKG, PRKG1B, PRKGR1B, cGK, cGK 1, cGK1, cGKI, cGKI-BETA, cGKI-alpha
物種:
Human PRKG1 (5592), Mouse Prkg1 (19091), Rat Prkg1 (54286), cow PRKG1 (282004), sheep PRKG1 (101117124), sheep PRKG1 (100294616), domestic guinea pig Prkg1 (100734084), Domestic Rabbit PRKG1 (100008694), naked mole-rat Prkg1 (101708361), chicken PRKG1 (423682) ...更多
UniProtKB ID:
Q13976, E2PU10, P14619, Q5JSJ6, Q6P5T7
基因 ID:
  • Human(5592) Summary: Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity. [provided by RefSeq, Sep 2011]
  • Mouse(19091) protein kinase, cGMP-dependent, type I
  • Rat(54286) protein kinase, cGMP-dependent, type 1
  • cow(282004) protein kinase, cGMP-dependent, type I
  • sheep(101117124) protein kinase, cGMP-dependent, type I
  • sheep(100294616) protein kinase, cGMP-dependent, type I
  • domestic guinea pig(100734084) protein kinase, cGMP-dependent, type I
  • Domestic Rabbit(100008694) protein kinase, cGMP-dependent, type I
  • naked mole-rat(101708361) protein kinase, cGMP-dependent, type I
  • chicken(423682) protein kinase, cGMP-dependent, type I
  • dog(609616) protein kinase, cGMP-dependent, type I
  • Horse(100071872) protein kinase, cGMP-dependent, type I
  • domestic cat(101097420) protein kinase, cGMP-dependent, type I

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ELISA

Product Number
描述
物種
CG201
cGMP 酶免疫检测试剂盒, sufficient for 96 assays,
物種
human
CG200
cGMP 酶免试剂盒，直接, sufficient for 96 assays,
物種
human

Antibodies

Product Number
描述
物種活性
應用
09-101
Anti-cGMP (cyclic GMP) Antibody, serum, Upstate®,
物種活性
all
應用
ELISA
immunohistochemistry
radioimmunoassay
SAB1306183
ANTI-CGKI (CGKI BETA)(C-TERMINAL) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
物種活性
human, mouse
應用
immunohistochemistry
western blot

Proteins

Product Number
描述
物種
14-688-M
PKG1α 蛋白，活性 10 µg, Active, N-terminal 6His-tagged, recombinant, full length PKG1α. For use in Kinase Assays.,
物種
human
P3738
Protein Kinase G Iβ human, ≥95% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf9 cells, buffered aqueous glycerol solution,
物種
human
SRP0371
PKG1alpha active human, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE),
物種
human
14-650-M
PKG1β Protein, active, 10 µg, Active, N-terminal 6His-tagged, recombinant, full length PKG1β, for use in Kinase Assays.,
物種
human
R8282
PRKG1, active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
物種
human