LRP2
low density lipoprotein receptor-related protein 2
同義詞:
DBS, GP330
物種:
Human LRP2 (4036), Mouse Lrp2 (14725), Rat Lrp2 (29216), chicken LRP2 (424168), domestic cat LRP2 (101087337), cow LRP2 (100337021), Horse LRP2 (100062836), dog LRP2 (478781), naked mole-rat Lrp2 (101717800), Domestic Rabbit LRP2 (100346275) ...更多
UniProtKB ID:
基因 ID:
- Human(4036) Summary: The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).[provided by RefSeq, Aug 2009]
- Mouse(14725) low density lipoprotein receptor-related protein 2
- Rat(29216) low density lipoprotein receptor-related protein 2
- chicken(424168) low density lipoprotein receptor-related protein 2
- domestic cat(101087337) low density lipoprotein receptor-related protein 2
- cow(100337021) low density lipoprotein receptor-related protein 2
- Horse(100062836) low density lipoprotein receptor-related protein 2
- dog(478781) low density lipoprotein receptor-related protein 2
- naked mole-rat(101717800) low density lipoprotein receptor-related protein 2
- Domestic Rabbit(100346275) low density lipoprotein receptor-related protein 2
- domestic guinea pig(100713603) low density lipoprotein receptor-related protein 2
- sheep(101108200) low density lipoprotein receptor-related protein 2
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
產品編號
描述
物種活性
應用
ANTI-LRP2 (MEGALIN) (C-TERM) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
物種活性
human
應用
ELISA
immunohistochemistry
immunohistochemistry