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Merck

LIG4

ligase IV, DNA, ATP-dependent

同義詞:
物種:
UniProtKB ID:
基因 ID:
  • Human(3981) Summary: The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
  • Mouse(319583) ligase IV, DNA, ATP-dependent
  • Rat(290907) ligase IV, DNA, ATP-dependent
  • Zebrafish(569525) ligase IV, DNA, ATP-dependent
  • cow(781252) ligase IV, DNA, ATP-dependent
  • Horse(100051479) ligase IV, DNA, ATP-dependent
  • domestic cat(101087961) ligase IV, DNA, ATP-dependent
  • dog(485544) ligase IV, DNA, ATP-dependent
  • chicken(418764) ligase IV, DNA, ATP-dependent
  • fruit fly(32322) Ligase4
  • domestic guinea pig(100719171) ligase IV, DNA, ATP-dependent
  • naked mole-rat(101722009) ligase IV, DNA, ATP-dependent
  • sheep(101116239) ligase IV, DNA, ATP-dependent

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Antibodies

產品編號
描述
物種活性
應用
Monoclonal Anti-LIG4, (C-terminal) antibody produced in mouse, clone 2D2, purified immunoglobulin, buffered aqueous solution,
物種活性
human
應用
ELISA
western blot
Anti-LIG4 antibody produced in rabbit, IgG fraction of antiserum,
物種活性
human
應用
immunohistochemistry
western blot