LDLR
low density lipoprotein receptor
同義詞:
FH, FHC, LDLCQ2
物種:
Human LDLR (3949), Mouse Ldlr (16835), Rat Ldlr (300438), Zebrafish ldlr (387529), dog LDLR (100683160), chicken LDLR (395103), domestic cat LDLR (101080362), cow LDLR (281276), Domestic Rabbit LDLR (100009086), domestic guinea pig Ldlr (100724238)
UniProtKB ID:
基因 ID:
- Human(3949) Summary: The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]
- Mouse(16835) low density lipoprotein receptor
- Rat(300438) low density lipoprotein receptor
- Zebrafish(387529) low density lipoprotein receptor
- dog(100683160) low density lipoprotein receptor
- chicken(395103) low density lipoprotein receptor
- domestic cat(101080362) low density lipoprotein receptor
- cow(281276) low density lipoprotein receptor
- Domestic Rabbit(100009086) low density lipoprotein receptor
- domestic guinea pig(100724238) low density lipoprotein receptor
- naked mole-rat(101703463) low density lipoprotein receptor
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Antibodies
產品編號
描述
物種活性
應用
Anti-Low Density Lipoprotein Antibody, copper oxidized, serum, Chemicon®,
物種活性
human
應用
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-LDLR antibody produced in chicken, affinity isolated antibody, buffered aqueous solution,
物種活性
human, mouse, rat
應用
western blot
Anti-Low Density Lipoprotein Antibody, HOCL oxidized, serum, Chemicon®,
物種活性
human
應用
ELISA
immunohistochemistry
immunohistochemistry
Anti-LDL-R antibody produced in chicken, affinity isolated antibody, buffered aqueous solution,
物種活性
human, mouse, rat
應用
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
esiRNA
產品編號
描述
物種