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Merck

HMGCR

3-hydroxy-3-methylglutaryl-CoA reductase

同義詞:
LDLCQ3
物種:
UniProtKB ID:
基因 ID:
  • Human(3156) Summary: HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
  • Mouse(15357) 3-hydroxy-3-methylglutaryl-Coenzyme A reductase
  • Rat(25675) 3-hydroxy-3-methylglutaryl-CoA reductase
  • fruit fly(42803) HMG Coenzyme A reductase
  • chicken(395145) 3-hydroxy-3-methylglutaryl-CoA reductase
  • cow(407159) 3-hydroxy-3-methylglutaryl-CoA reductase
  • Horse(100065577) 3-hydroxy-3-methylglutaryl-CoA reductase
  • domestic cat(101098922) 3-hydroxy-3-methylglutaryl-CoA reductase
  • dog(479182) 3-hydroxy-3-methylglutaryl-CoA reductase
  • domestic guinea pig(100726509) 3-hydroxy-3-methylglutaryl-CoA reductase
  • naked mole-rat(101717005) 3-hydroxy-3-methylglutaryl-CoA reductase
  • sheep(101108919) 3-hydroxy-3-methylglutaryl-CoA reductase

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Activity Assay

Product Number
描述
物種
HMG-CoA 还原酶检测试剂盒, sufficient for 30 assays (1 mL), sufficient for 100 assays (200 μL),
物種
human

Antibodies

Product Number
描述
物種活性
應用
Monoclonal Anti-HMGCR antibody produced in mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL0259, purified immunoglobulin, buffered aqueous glycerol solution,
物種活性
human
應用
immunohistochemistry
western blot
HMG-CoA还原酶抗体,克隆IgG-A9, clone IgG-A9, from mouse,
物種活性
hamster, human, rat
應用
immunocytochemistry
immunoprecipitation (IP)

western blot
Anti-HMG-CoA reductase Antibody, from rabbit, purified by affinity chromatography,
物種活性
human, primate
應用
immunoprecipitation (IP)
western blot
Anti-HMGCR (internal) antibody produced in rabbit, ~1.0 mg/mL, affinity isolated antibody,
物種活性
human, mouse, rat
應用
western blot
Anti-HMGCR antibody produced in rabbit, ~1.0 mg/mL, affinity isolated antibody,
物種活性
human
應用
immunofluorescence
western blot

Small Molecule - Inhibitor

Product Number
描述
物種
(+)-γ-生育酚, ≥96% (HPLC),
物種
human
(+)-γ-生育酚, analytical standard,
物種
human
辛伐他汀, Pharmaceutical Secondary Standard; Certified Reference Material,
物種
human
普伐他汀 钠盐 水合物, ≥98% (HPLC), powder,
物種
human
辛伐他汀, United States Pharmacopeia (USP) Reference Standard,
物種
human

Proteins

Product Number
描述
物種
3-羟基-3-甲基戊二酰-CoA 还原酶 人, solution,
物種
human

esiRNA

Product Number
描述
物種
MISSION® esiRNA, targeting human HMGCR,
物種
human