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Merck

EGFR

epidermal growth factor receptor

同義詞:
ERBB, ERBB1, HER1, PIG61, mENA
物種:
Human EGFR (1956), Mouse Egfr (13649), Rat Egfr (24329), fruit fly Egfr (37455), cow EGFR (407217), Horse EGFR (100067755), domestic cat EGFR (100510799), dog EGFR (404306), chicken EGFR (396494), domestic guinea pig Egfr (100725363) ...更多
UniProtKB ID:
P00533, O00688, O00732, P06268, Q14225, Q68GS5, Q92795, Q9BZS2
基因 ID:
  • Human(1956) Summary: The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
  • Mouse(13649) epidermal growth factor receptor
  • Rat(24329) epidermal growth factor receptor
  • fruit fly(37455) Epidermal growth factor receptor
  • cow(407217) epidermal growth factor receptor
  • Horse(100067755) epidermal growth factor receptor
  • domestic cat(100510799) epidermal growth factor receptor
  • dog(404306) epidermal growth factor receptor
  • chicken(396494) epidermal growth factor receptor
  • domestic guinea pig(100725363) epidermal growth factor receptor
  • naked mole-rat(101723771) epidermal growth factor receptor
  • sheep(780479) epidermal growth factor receptor

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ELISA

Product Number
描述
物種
RAB0160
人EGFR/ ErbB1 ELISA试剂盒, for serum, plasma, cell culture supernatants and urine,
物種
human
RAB0159
基于细胞的磷酸化EGFR ELISA采样器套件, for detecting phospho-egfr(pTyr845), phospho-egfr(pTyr992), phospho-egfr(pTyr1068) and phospho-egfr in cultured cell lines,
物種
human

Small Molecule - Antagonist

Product Number
描述
物種
T4182
Tyrphostin AG 1478（酪氨酸激酶抑制剂AG 1478）, ≥98%,
物種
human, mouse
S8442
SU 5416, ≥98% (HPLC),
物種
human, mouse
G6649
染料木黄酮, synthetic, ≥98% (HPLC), powder,
物種
mouse, human, rat
G6776
染料木黄酮, from Glycine max (soybean), ~98% (HPLC),
物種
mouse, human, rat

Antibodies

Product Number
描述
物種活性
應用
MABS1915M
Anti-EGFRvIII Antibody, clone DH8.3, clone DH8.3, from mouse,
物種活性
human
應用
ELISA
flow cytometry
immunohistochemistry
immunoprecipitation (IP)
western blot
05-104
Anti-EGFR Antibody, clone LA22, clone LA22, Upstate®, from mouse,
物種活性
human
應用
immunocytochemistry
immunoprecipitation (IP)
western blot
E2906
抗-dEGF受体，细胞外结构域抗体，小鼠单克隆, clone C-273, purified from hybridoma cell culture,
物種活性
drosophila
應用
ELISA
immunohistochemistry
western blot
05-101
抗-EGFR抗体，中和，克隆LA1, clone LA1, Upstate®, from mouse,
物種活性
human
應用
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
neutralization
western blot
E3138
抗-表皮生长因子受体单克隆抗体 小鼠抗, clone F4, ascites fluid,
物種活性
human
應用
ELISA
immunohistochemistry
immunoprecipitation (IP)
microarray
western blot

Small Molecule - Inhibitor

Product Number
描述
物種
SML1657
吉非替尼, ≥98% (HPLC),
物種
human
CDS022564
厄洛替尼盐酸盐, ,
物種
human
D3943
DAPH, ≥98% (HPLC), solid,
物種
human
T7040
Tyrphostin 1, ≥98%,
物種
human
SML1095
PKI-166, ≥98% (HPLC),
物種
human

Proteins

Product Number
描述
物種
E2645
Epidermal Growth Factor Receptor human, lyophilized powder, ≥15,000 units/mg protein (Bradford),
物種
human
SRP0239
EGFR Active human, recombinant, expressed in baculovirus infected insect cells, ≥70% (SDS-PAGE),
物種
human
SRP6404
EGFR/ErbB1 human, recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE),
物種
human
SRP0242
EGFR (T790M L858R) Active human, recombinant, expressed in baculovirus infected insect cells, ≥70% (SDS-PAGE),
物種
human
SRP3028
EGF-receptor human, recombinant, expressed in CHO cells, ≥95% (SDS-PAGE), ≥95% (HPLC), suitable for cell culture,
物種
human