DUSP3
dual specificity phosphatase 3
同義詞:
VHR
物種:
Human DUSP3 (1845), Mouse Dusp3 (72349), Rat Dusp3 (498003), chicken DUSP3 (425527), dog DUSP3 (480505), cow DUSP3 (615432), domestic cat DUSP3 (101083983), sheep DUSP3 (101114374), naked mole-rat Dusp3 (101702703), domestic guinea pig Dusp3 (100730437)
UniProtKB ID:
基因 ID:
- Human(1845) Summary: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1. [provided by RefSeq, Jul 2008]
- Mouse(72349) dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)
- Rat(498003) dual specificity phosphatase 3
- chicken(425527) dual specificity phosphatase 3
- dog(480505) dual specificity phosphatase 3
- cow(615432) dual specificity phosphatase 3
- domestic cat(101083983) dual specificity phosphatase 3
- sheep(101114374) dual specificity phosphatase 3
- naked mole-rat(101702703) dual specificity phosphatase 3
- domestic guinea pig(100730437) dual specificity phosphatase 3
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