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Merck

DNMT3L

DNA (cytosine-5-)-methyltransferase 3-like

同義詞:
物種:
UniProtKB ID:
基因 ID:
  • Human(29947) Summary: CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases, but is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, it does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]
  • Mouse(54427) DNA (cytosine-5-)-methyltransferase 3-like
  • Rat(309680) DNA (cytosine-5-)-methyltransferase 3-like
  • domestic guinea pig(100729608) DNA (cytosine-5-)-methyltransferase 3-like
  • naked mole-rat(101719207) DNA (cytosine-5-)-methyltransferase 3-like
  • sheep(101102451) DNA (cytosine-5-)-methyltransferase 3-like
  • dog(608536) DNA (cytosine-5-)-methyltransferase 3-like
  • domestic cat(101091300) DNA (cytosine-5-)-methyltransferase 3-like
  • cow(613785) DNA (cytosine-5-)-methyltransferase 3-like
  • Horse(100050680) DNA (cytosine-5-)-methyltransferase 3-like

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Antibodies

產品編號
描述
物種活性
應用
Anti-DNMT3L, from rabbit,
物種活性
mouse
應用
immunocytochemistry
immunofluorescence

western blot

Proteins

產品編號
描述
物種
DNMT3A/DNMT3L,活性,人, recombinant, expressed in baculovirus infected Sf9 cells, ≥90% (SDS-PAGE),
物種
human