CYP27B1

cytochrome P450, family 27, subfamily B, polypeptide 1

同義詞:

CP2B, CYP1, CYP1alpha, CYP27B, P450c1, PDDR, VDD1, VDDR, VDDRI, VDR

物種:

UniProtKB ID:

基因 ID:

Human(1594) Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the inner mitochondrial membrane where it hydroxylates 25-hydroxyvitamin D3 at the 1alpha position. This reaction synthesizes 1alpha,25-dihydroxyvitamin D3, the active form of vitamin D3, which binds to the vitamin D receptor and regulates calcium metabolism. Thus this enzyme regulates the level of biologically active vitamin D and plays an important role in calcium homeostasis. Mutations in this gene can result in vitamin D-dependent rickets type I. [provided by RefSeq, Jul 2008]
Mouse(13115) cytochrome P450, family 27, subfamily b, polypeptide 1
Rat(114700) cytochrome P450, family 27, subfamily b, polypeptide 1
domestic cat(100750221) cytochrome P450, family 27, subfamily B, polypeptide 1
dog(481133) cytochrome P450, family 27, subfamily B, polypeptide 1
Horse(100034100) cytochrome P450, family 27, subfamily B, polypeptide 1
cow(539630) cytochrome P450, family 27, subfamily B, polypeptide 1

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產品編號

描述

物種活性

應用

Anti-CYP27B1 Antibody, from rabbit, purified by affinity chromatography,

物種活性

chimpanzee, human, mouse, rat

應用

immunohistochemistry
western blot