C5
complement component 5
同義詞:
C5a, C5b, CPAMD4
物種:
Human C5 (727), Rat C5 (362119), Zebrafish c5 (565774), cow C5 (512045), domestic cat C5 (101090401), dog C5 (474816), chicken C5 (417122), sheep C5 (101121825), naked mole-rat C5 (101710435), domestic guinea pig C5 (100733000)
UniProtKB ID:
基因 ID:
- Human(727) Summary: The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components. Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis. [provided by RefSeq, Jul 2008]
- Rat(362119) complement component 5
- Zebrafish(565774) complement component 5
- cow(512045) complement component 5
- domestic cat(101090401) complement component 5
- dog(474816) complement component 5
- chicken(417122) complement component 5
- sheep(101121825) complement component 5
- naked mole-rat(101710435) complement component 5
- domestic guinea pig(100733000) complement component 5
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