C4B
complement component 4B (Chido blood group)
同義詞:
C4B1, C4B12, C4B2, C4B3, C4B5, C4BD, C4B_2, C4F, CH, CO4, CPAMD3
物種:
Human C4B (721), Mouse C4b (12268), Rat C4b (406161), cow C4B (100851057), domestic cat C4B (101094346)
UniProtKB ID:
基因 ID:
- Human(721) Summary: This gene encodes the basic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. In addition, this gene exists as a long form and a short form due to the presence or absence of a 6.4 kb endogenous HERV-K retrovirus in intron 9. [provided by RefSeq, Jul 2008]
- Mouse(12268) complement component 4B (Chido blood group)
- Rat(406161) complement component 4B (Chido blood group)
- cow(100851057) complement component 4B (Chido blood group)
- domestic cat(101094346) complement component 4B (Chido blood group)
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Antibodies
產品編號
描述
物種活性
應用
Anti-C4D antibody, Rabbit monoclonal, recombinant, expressed in proprietary host, clone SP91, affinity isolated antibody,
物種活性
human
應用
immunohistochemistry