BCR
breakpoint cluster region
同義詞:
ALL, BCR1, CML, D22S11, D22S662, PHL
物種:
Human BCR (613), Mouse Bcr (110279), Rat Bcr (309696), Zebrafish bcr (568320), domestic cat BCR (101101671), cow BCR (789892), dog BCR (607482), chicken BCR (416952), Domestic Rabbit BCR (100339436), naked mole-rat Bcr (101716702)
UniProtKB ID:
基因 ID:
- Human(613) Summary: A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Mouse(110279) breakpoint cluster region
- Rat(309696) breakpoint cluster region
- Zebrafish(568320) breakpoint cluster region
- domestic cat(101101671) breakpoint cluster region
- cow(789892) breakpoint cluster region
- dog(607482) breakpoint cluster region
- chicken(416952) breakpoint cluster region
- Domestic Rabbit(100339436) breakpoint cluster region
- naked mole-rat(101716702) breakpoint cluster region
- domestic guinea pig(100718992) breakpoint cluster region
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Antibodies
產品編號
描述
物種活性
應用
Anti-phospho-Bcr (pTyr360) antibody produced in rabbit, affinity isolated antibody,
物種活性
human, mouse
應用
western blot
Proteins
產品編號
描述
物種
BCR (1-695), GST tagged human, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
物種
human