ALPL
alkaline phosphatase, liver/bone/kidney
同義詞:
AP-TNAP, APTNAP, HOPS, TNAP, TNSALP
物種:
Human ALPL (249), Mouse Alpl (11647), Rat Alpl (25586), Zebrafish alpl (393982), domestic cat ALPL (727689), dog ALPL (403548), chicken ALPL (396317), cow ALPL (280994), naked mole-rat Alpl (101725910), domestic guinea pig Alpl (100718683)
UniProtKB ID:
基因 ID:
- Human(249) Summary: There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]
- Mouse(11647) alkaline phosphatase, liver/bone/kidney
- Rat(25586) alkaline phosphatase, liver/bone/kidney
- Zebrafish(393982) alkaline phosphatase, liver/bone/kidney
- domestic cat(727689) alkaline phosphatase, liver/bone/kidney
- dog(403548) alkaline phosphatase, liver/bone/kidney
- chicken(396317) alkaline phosphatase, liver/bone/kidney
- cow(280994) alkaline phosphatase, liver/bone/kidney
- naked mole-rat(101725910) alkaline phosphatase, liver/bone/kidney
- domestic guinea pig(100718683) alkaline phosphatase, liver/bone/kidney
- sheep(101123195) alkaline phosphatase, liver/bone/kidney
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Antibodies
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描述
物種活性
應用
单克隆抗-FLAG®碱性磷酸酶 小鼠抗, clone M2, purified immunoglobulin, buffered aqueous glycerol solution,
物種活性
all
應用
ELISA
Monoclonal Anti-ALPL antibody produced in mouse, clone 2F4, purified immunoglobulin, buffered aqueous solution,
物種活性
human
應用
ELISA
flow cytometry
immunohistochemistry
western blot
flow cytometry
immunohistochemistry
western blot
Anti-ALPL antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
物種活性
human
應用
immunoprecipitation (IP)
western blot
western blot
Small Molecule - Inhibitor
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Kits
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esiRNA
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