- Analytical methodologies for the determination of omeprazole: an overview.
Analytical methodologies for the determination of omeprazole: an overview.
Journal of pharmaceutical and biomedical analysis (2007-05-29)
M Espinosa Bosch, A J Ruiz Sánchez, F Sánchez Rojas, C Bosch Ojeda
PMID17532167
ABSTRACT
Omeprazole, a gastric acid pump inhibitor, dose-dependently controls gastric acid secretion; the drug has greater antisecretory activity than histamine H(2)-receptor antagonists. Omeprazole has been determined in formulations and biological fluids by a variety of methods such as spectrophotometry, high-performance liquid chromatography with ultraviolet detection and liquid chromatography coupled with tandem mass spectrometry. The overview includes the most relevant analytical methodologies used in its determination since the origin still today.
MATERIALS
Product Number
Brand
Product Description
Omeprazole, European Pharmacopoeia (EP) Reference Standard