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G7403

Sigma-Aldrich

Glycine

≥99% (titration), suitable for electron microscopy, BioXtra

Synonym(s):

Aminoacetic acid, Aminoethanoic acid, Glycocoll

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About This Item

Linear Formula:
NH2CH2COOH
CAS Number:
56-40-6
Molecular Weight:
75.07
Beilstein:
635782
EC Number:
200-272-2
MDL number:
MFCD00008131
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
24895306
NACRES:
NA.26
Pricing and availability is not currently available.

Product Name

Glycine, BioXtra, ≥99% (titration)

product line

BioXtra

Quality Level

200

Assay

≥99% (titration)

form

powder

technique(s)

electron microscopy: suitable

impurities

Insoluble matter, passes filter test

ign. residue

≤0.05%

loss

≤0.05% loss on drying, HV, 20-26 °C

color

white

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Application

Glycine has been used to quench unreacted aldehyde during sample (nuclei) preparation for scanning electron microscope.[1] It has also been used for sample fixation in the process of immunolabeling.[2]

Biochem/physiol Actions

Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.
Glycine is a non-essential amino acid.[3] Influx of calcium through the cell membrane is mediated by glycine-gated channel. Glycine participates in the synthesis of porphyrins, purine and serine. It also serves as a competitive agonist for glutamate in binding to the NMDA (N-methyl-D-aspartate) receptors.[4] Glycine synthesis might be increased in rapidly proliferating cancer cells, due to increased demand for the amino acid.[3]

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves
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    Lot/Batch Number
    SLCJ7999
    BCCF9126
    BCCD6779
    SLCF8593
    SLCD7014

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    Pre-embedding immunogold labeling to optimize protein localization at subcellular compartments and membrane microdomains of leukocytes.
    Melo RC
    Nature Protocols, 9(10), 2382-2394 (2014)
    Visualization of the nucleus and nuclear envelope in situ by SEM in tissue culture cells.
    Allen TD
    Nature Protocols, 2(5), 1180-1184 (2007)
    Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation
    Mohit Jain
    Science, 336(6084), 1040-1044 (2012)
    Amino acids: metabolism, functions, and nutrition.
    Wu G
    Amino Acids, 37(1), 1-17 (2009)
    Alexander Carvajal-González et al.
    Brain : a journal of neurology, 137(Pt 8), 2178-2192 (2014-06-22)
    The clinical associations of glycine receptor antibodies have not yet been described fully. We identified prospectively 52 antibody-positive patients and collated their clinical features, investigations and immunotherapy responses. Serum glycine receptor antibody endpoint titres ranged from 1:20 to 1:60 000.
    View All Related Papers

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