Skip to Content
Merck

TPO

thyroid peroxidase

Synonyms:
MSA, TDH2A, TPX
Species:
UniProtKB ID:
Gene ID:
  • Human(7173) Summary: This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2011]
  • Mouse(22018) thyroid peroxidase
  • Rat(54314) thyroid peroxidase
  • cow(525013) thyroid peroxidase
  • naked mole-rat(101704548) thyroid peroxidase
  • domestic guinea pig(100723704) thyroid peroxidase
  • chicken(776120) thyroid peroxidase
  • domestic cat(101098706) thyroid peroxidase
  • dog(403521) thyroid peroxidase

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

ELISA

Product Number
Description
Species
Human TPO / Thyroid Peroxidase ELISA Kit, for serum, plasma, cell culture supernatants and urine,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-TPO antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunohistochemistry

western blot
Anti-TPO antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
Methimazole, analytical standard,
Species
human
Methimazole, VETRANAL®, analytical standard,
Species
human
Thiamazole, European Pharmacopoeia (EP) Reference Standard,
Species
human
Methimazole, United States Pharmacopeia (USP) Reference Standard,
Species
human
6-Propyl-2-thiouracil, enzyme inhibitor,
Species
human

Proteins

Product Number
Description
Species
Thrombopoietin, TPO (Thrombopoietin, Mpl-ligand, MGDF) stimulates the proliferation & maturation of megakaryocytes & promotes increased circulating levels of platelets in vivo.,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human TPO,
Species
human