TNNI1
troponin I type 1 (skeletal, slow)
Synonyms:
SSTNI, TNN1
Species:
Human TNNI1 (7135), Mouse Tnni1 (21952), Rat Tnni1 (29388), cow TNNI1 (100301375), Goat TNNI1 (100860774), domestic guinea pig Tnni1 (100733717), naked mole-rat Tnni1 (101720739), chicken TNNI1 (421161), domestic cat TNNI1 (101096197), dog TNNI1 (100685160)
UniProtKB ID:
Gene ID:
- Human(7135) Summary: Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes. [provided by RefSeq, Jul 2008]
- Mouse(21952) troponin I, skeletal, slow 1
- Rat(29388) troponin I type 1 (skeletal, slow)
- cow(100301375) troponin I type 1 (skeletal, slow)
- Goat(100860774) troponin I type 1 (skeletal, slow)
- domestic guinea pig(100733717) troponin I type 1 (skeletal, slow)
- naked mole-rat(101720739) troponin I type 1 (skeletal, slow)
- chicken(421161) troponin I type 1 (skeletal, slow)
- domestic cat(101096197) troponin I type 1 (skeletal, slow)
- dog(100685160) troponin I type 1 (skeletal, slow)
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-TNNI1 (AB1) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
western blot
Proteins
Product Number
Description
Species
Troponin1, His tagged human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human