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Merck

SNTA1

syntrophin, alpha 1

Synonyms:
LQT12, SNT1, TACIP1, dJ1187J4.5
Species:
Human SNTA1 (6640), Mouse Snta1 (20648), Rat Snta1 (362242), domestic cat SNTA1 (101098944), dog SNTA1 (485837), cow SNTA1 (527488), sheep SNTA1 (101109469), domestic guinea pig Snta1 (100732931), naked mole-rat Snta1 (101721241), Domestic Rabbit SNTA1 (100009179)
UniProtKB ID:
Q13424, A8K7H9, E1P5N1, Q16438
Gene ID:
  • Human(6640) Summary: Syntrophins are cytoplasmic peripheral membrane scaffold proteins that are components of the dystrophin-associated protein complex. This gene is a member of the syntrophin gene family and encodes the most common syntrophin isoform found in cardiac tissues. The N-terminal PDZ domain of this syntrophin protein interacts with the C-terminus of the pore-forming alpha subunit (SCN5A) of the cardiac sodium channel Nav1.5. This protein also associates cardiac sodium channels with the nitric oxide synthase-PMCA4b (plasma membrane Ca-ATPase subtype 4b) complex in cardiomyocytes. This gene is a susceptibility locus for Long-QT syndrome (LQT) - an inherited disorder associated with sudden cardiac death from arrhythmia - and sudden infant death syndrome (SIDS). This protein also associates with dystrophin and dystrophin-related proteins at the neuromuscular junction and alters intracellular calcium ion levels in muscle tissue. [provided by RefSeq, Jan 2013]
  • Mouse(20648) syntrophin, acidic 1
  • Rat(362242) syntrophin, alpha 1
  • domestic cat(101098944) syntrophin, alpha 1
  • dog(485837) syntrophin, alpha 1
  • cow(527488) syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)
  • sheep(101109469) syntrophin, alpha 1
  • domestic guinea pig(100732931) syntrophin, alpha 1
  • naked mole-rat(101721241) syntrophin, alpha 1
  • Domestic Rabbit(100009179) syntrophin, alpha 1

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Antibodies

Product Number
Description
Species Reactivity
Application
S4813
Anti-α1-Syntrophin (RA-16) antibody produced in rabbit, buffered aqueous solution, IgG fraction of antiserum,
Species Reactivity
rat
Application
immunohistochemistry
microarray
western blot