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Merck

RNASEH2A

ribonuclease H2, subunit A

Synonyms:
AGS4, JUNB, RNASEHI, RNHIA, RNHL
Species:
Human RNASEH2A (10535), Mouse Rnaseh2a (69724), Rat Rnaseh2a (364974), Zebrafish rnaseh2a (393195), domestic cat RNASEH2A (101086121), dog RNASEH2A (484925), cow RNASEH2A (512830), sheep RNASEH2A (101105746), Goat RNASEH2A (100860936), domestic guinea pig Rnaseh2a (100715505)
UniProtKB ID:
O75792, B2RCY1, Q96F11
Gene ID:
  • Human(10535) Summary: The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme (RNAseH2). RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to excise single ribonucleotides from DNA-DNA duplexes. Mutations in this gene cause Aicardi-Goutieres Syndrome (AGS), a an autosomal recessive neurological disorder characterized by progressive microcephaly and psychomotor retardation, intracranial calcifications, elevated levels of interferon-alpha and white blood cells in the cerebrospinal fluid.[provided by RefSeq, Aug 2009]
  • Mouse(69724) ribonuclease H2, large subunit
  • Rat(364974) ribonuclease H2, subunit A
  • Zebrafish(393195) ribonuclease H2, subunit A
  • domestic cat(101086121) ribonuclease H2, subunit A
  • dog(484925) ribonuclease H2, subunit A
  • cow(512830) ribonuclease H2, subunit A
  • sheep(101105746) ribonuclease H2, subunit A
  • Goat(100860936) ribonuclease H2, subunit A
  • domestic guinea pig(100715505) ribonuclease H2, subunit A
  • naked mole-rat(101714999) ribonuclease H2, subunit A

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Antibodies

Product Number
Description
Species Reactivity
Application
SAB1407007
Anti-RNASEH2A antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
immunofluorescence
western blot
AV40646
Anti-RNASEH2A antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
immunohistochemistry
western blot
AV40647
Anti-RNASEH2A antibody produced in rabbit, IgG fraction of antiserum,
Species Reactivity
bovine, goat, horse, human, pig
Application
immunohistochemistry
western blot