RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
Synonyms:
GRP3
Species:
Human RASGRP3 (25780), Mouse Rasgrp3 (240168), Rat Rasgrp3 (313874), Zebrafish rasgrp3 (563441), chicken RASGRP3 (421460), Horse RASGRP3 (100070505), dog RASGRP3 (611329), domestic guinea pig Rasgrp3 (100712845), naked mole-rat Rasgrp3 (101717811), Domestic Rabbit RASGRP3 (100342183) ...More
UniProtKB ID:
Gene ID:
- Human(25780) Summary: Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]
- Mouse(240168) RAS, guanyl releasing protein 3
- Rat(313874) RAS guanyl releasing protein 3 (calcium and DAG-regulated)
- Zebrafish(563441) RAS guanyl releasing protein 3 (calcium and DAG-regulated)
- chicken(421460) RAS guanyl releasing protein 3 (calcium and DAG-regulated)
- Horse(100070505) RAS guanyl releasing protein 3 (calcium and DAG-regulated)
- dog(611329) RAS guanyl releasing protein 3 (calcium and DAG-regulated)
- domestic guinea pig(100712845) RAS guanyl releasing protein 3 (calcium and DAG-regulated)
- naked mole-rat(101717811) RAS guanyl releasing protein 3 (calcium and DAG-regulated)
- Domestic Rabbit(100342183) RAS guanyl releasing protein 3 (calcium and DAG-regulated)
- cow(523745) RAS guanyl releasing protein 3 (calcium and DAG-regulated)
- sheep(101101969) RAS guanyl releasing protein 3 (calcium and DAG-regulated)
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