RAB8A
RAB8A, member RAS oncogene family
Synonyms:
MEL, RAB8
Species:
Human RAB8A (4218), Mouse Rab8a (17274), Rat Rab8a (117103), Thale Cress RAB8A (823749), chicken RAB8A (428352), dog RAB8A (403773), domestic cat RAB8A (101092668), Zebrafish rab8a (571897), naked mole-rat Rab8a (101709178), domestic guinea pig Rab8a (100734132) ...More
UniProtKB ID:
Gene ID:
- Human(4218) Summary: The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1. [provided by RefSeq, Jul 2008]
- Mouse(17274) RAB8A, member RAS oncogene family
- Rat(117103) RAB8A, member RAS oncogene family
- Thale Cress(823749) small GTP-binding protein ARA3
- chicken(428352) RAB8A, member RAS oncogene family
- dog(403773) RAB8A, member RAS oncogene family
- domestic cat(101092668) RAB8A, member RAS oncogene family
- Zebrafish(571897) RAB8A, member RAS oncogene family
- naked mole-rat(101709178) RAB8A, member RAS oncogene family
- domestic guinea pig(100734132) RAB8A, member RAS oncogene family
- cow(100125881) RAB8A, member RAS oncogene family
- sheep(100302063) RAB8A, member RAS oncogene family
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Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-RAB8A antibody produced in mouse, clone 3G1, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot
Anti-Rab8 antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
western blot
western blot