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Merck

POLR2A

polymerase (RNA) II (DNA directed) polypeptide A, 220kDa

Synonyms:
POLR2, POLRA, RPB1, RPBh1, RPO2, RPOL2, RpIILS, hRPB220, hsRPB1
Species:
Human POLR2A (5430), Mouse Polr2a (20020), Rat Polr2a (363633), domestic guinea pig Polr2a (100734232), naked mole-rat Polr2a (101725588), cow POLR2A (282312), sheep POLR2A (100144762), Zebrafish polr2a (553347), dog POLR2A (479483), domestic cat POLR2A (101098500)
UniProtKB ID:
P24928, A6NN93, B9EH88
Gene ID:
  • Human(5430) Summary: This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. [provided by RefSeq, Jul 2008]
  • Mouse(20020) polymerase (RNA) II (DNA directed) polypeptide A
  • Rat(363633) polymerase (RNA) II (DNA directed) polypeptide A
  • domestic guinea pig(100734232) polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
  • naked mole-rat(101725588) polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
  • cow(282312) polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
  • sheep(100144762) polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
  • Zebrafish(553347) polymerase (RNA) II (DNA directed) polypeptide A
  • dog(479483) polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
  • domestic cat(101098500) polymerase (RNA) II (DNA directed) polypeptide A, 220kDa

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Antibodies

Product Number
Description
Species Reactivity
Application
SAB1408705
Monoclonal Anti-POLR2A, (N-terminal) antibody produced in mouse, clone IF17, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
05-952-I
Anti-RNA Polymerase II Antibody, CTD Antibody, clone 8WG16, clone 8WG16, from mouse,
Species Reactivity
human, yeast
Application
dot blot
immunoprecipitation (IP)
inhibition assay
western blot
CBL221
Anti-RNA Polymerase II Antibody, clone ARNA-3, ascites fluid, clone ARNA-3, Chemicon®,
Species Reactivity
drosophila, human, kangaroo
Application
immunohistochemistry
western blot
PLA0292
Goat anti-RNA Polymerase II Antibody, Affinity Purified, Powered by Bethyl Laboratories, Inc.,
Species Reactivity
human, mouse
Application
immunoprecipitation (IP)
western blot
SAB4200637
Monoclonal Anti-phospho-RNA polymerase II CTD (pSer2) antibody produced in rat, clone 3E7C7, purified from hybridoma cell culture,
Species Reactivity
Application
flow cytometry
immunofluorescence
western blot

Proteins

Product Number
Description
Species
SRP2120
RNA Polymerase II, C-terminal domain, GST tagged human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE),
Species
human
SRP2013
RNA Polymerase II, C-terminal human, recombinant, expressed in E. coli, ≥85% (SDS-PAGE),
Species
human

esiRNA

Product Number
Description
Species
EHU003451
MISSION® esiRNA, targeting human POLR2A,
Species
human