PLAU
plasminogen activator, urokinase
Synonyms:
ATF, BDPLT5, QPD, UPA, URK, u-PA
Species:
Human PLAU (5328), Mouse Plau (18792), Rat Plau (25619), chicken PLAU (396424), domestic cat PLAU (101098338), dog PLAU (403426), Domestic Rabbit PLAU (100008633), naked mole-rat Plau (101717852), domestic guinea pig Plau (100726129), cow PLAU (281408)
UniProtKB ID:
Gene ID:
- Human(5328) Summary: This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
- Mouse(18792) plasminogen activator, urokinase
- Rat(25619) plasminogen activator, urokinase
- chicken(396424) plasminogen activator, urokinase
- domestic cat(101098338) plasminogen activator, urokinase
- dog(403426) plasminogen activator, urokinase
- Domestic Rabbit(100008633) plasminogen activator, urokinase
- naked mole-rat(101717852) plasminogen activator, urokinase
- domestic guinea pig(100726129) plasminogen activator, urokinase
- cow(281408) plasminogen activator, urokinase
- sheep(100302501) plasminogen activator, urokinase
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-Plasminogen Activator/PLAU antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot
Anti-Urokinase Antibody, NT fragment, clone 2G6.2, clone 2G6.2, Chemicon®, from mouse,
Species Reactivity
human
Application
ELISA
western blot
western blot
Anti-Urokinase Antibody, NT fragment, clone 10D.7.2, clone 10D.7.2, Chemicon®, from mouse,
Species Reactivity
human
Application
ELISA
western blot
western blot
Small Molecule - Inhibitor
Kits
Product Number
Description
Species
uPA Activity Assay Kit, The uPA Activity Assay Kit provides a quick, efficient & sensitive system for evaluation of uPA activity & for screening of uPA inhibitors.,
Species
human
PAI Activity Assay, The PAI Activity Assay Kit provides a quick, efficient & sensitive system for evaluation of inhibition of uPA activity by PAI & for screening of uPA inhibitors.,
Species
human
Proteins
Product Number
Description
Species