PCMT1
protein-L-isoaspartate (D-aspartate) O-methyltransferase
Synonyms:
PIMT
Species:
Human PCMT1 (5110), Mouse Pcmt1 (18537), Rat Pcmt1 (25604), chicken PCMT1 (428607), domestic cat PCMT1 (101081732), dog PCMT1 (476242), cow PCMT1 (613854), sheep PCMT1 (101104502), domestic guinea pig Pcmt1 (100731541), naked mole-rat Pcmt1 (101723169)
UniProtKB ID:
Gene ID:
- Human(5110) Summary: This gene encodes a member of the type II class of protein carboxyl methyltransferase enzymes. The encoded enzyme plays a role in protein repair by recognizing and converting D-aspartyl and L-isoaspartyl residues resulting from spontaneous deamidation back to the normal L-aspartyl form. The encoded protein may play a protective role in the pathogenesis of Alzheimer's disease, and single nucleotide polymorphisms in this gene have been associated with spina bifida and premature ovarian failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
- Mouse(18537) protein-L-isoaspartate (D-aspartate) O-methyltransferase 1
- Rat(25604) protein-L-isoaspartate (D-aspartate) O-methyltransferase 1
- chicken(428607) protein-L-isoaspartate (D-aspartate) O-methyltransferase
- domestic cat(101081732) protein-L-isoaspartate (D-aspartate) O-methyltransferase
- dog(476242) protein-L-isoaspartate (D-aspartate) O-methyltransferase
- cow(613854) protein-L-isoaspartate (D-aspartate) O-methyltransferase
- sheep(101104502) protein-L-isoaspartate (D-aspartate) O-methyltransferase
- domestic guinea pig(100731541) protein-L-isoaspartate (D-aspartate) O-methyltransferase
- naked mole-rat(101723169) protein-L-isoaspartate (D-aspartate) O-methyltransferase
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